A Novel Therapeutic
We’re creating the first potential treatment for Demodex blepharitis
What is TP-03?
TP-03 is a topical ophthalmic formulation of lotilaner that, if approved, may offer treatment for millions of patients with Demodex blepharitis.1
Up to 25 million patients with Demodex blepharitis in the US have been left without an FDA-approved treatment.1-3
TP-03 may change that.
- Designed to resolve the signs of Demodex blepharitis by targeting and eradicating the root cause of the disease–Demodex mite infestation2
- Paralyzes and eradicates Demodex mites by selectively inhibiting parasite-specific GABA-Cl channels2
- Evaluated in 2 pivotal trials collectively involving 833 patients, both of which successfully met all primary and secondary end points; TP-03 had no serious treatment-related adverse events and was generally safe and well tolerated1
- TP-03 may potentially become the first FDA-approved therapy and definitive standard of care to treat millions of patients with Demodex blepharitis, if approved1
The active ingredient in TP-03 is lotilaner, a well-characterized antiparasitic agent that targets parasite-specific GABA-CI channels.1
Saturn-1 Phase 2b/3 Pivotal Trial
References
1. Tarsus announces positive topline data from Saturn-2 Phase 3, the second pivotal trial of TP-03 for the treatment of Demodex blepharitis, and expects to file a new drug application this year. News release. Tarsus Pharmaceuticals, Inc; May 2, 2022. 2. Tarsus Pharmaceuticals, Inc. announces positive results of Saturn-1 pivotal trial evaluating TP-03 for the treatment of Demodex blepharitis. Tarsus Pharmaceuticals, Inc. Press release. July 21, 2021. 3. Sadri E, Yeu L, Trattler W, Holdbrook M, Baba S. The prevalence of collarettes and Demodex blepharitis in ophthalmology and optometry practices. Presented at: ASCRS 2021. July 24, 2021; Las Vegas, NV. 4. Wilson FA, Stimpson JP, Wang Y. Inconsistencies exist in national estimates of eye care services utilization in the United States. J Ophthalmol. Published online August 9, 2015. doi:10.1155/2015/435606
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