In the United States, Demodex mites cause approximately 45% of blepharitis cases, a common ocular condition characterized by inflammation of the eyelid and affecting up to 20 million Americans.1-4
There are approximately 9 million patients without an FDA-approved therapy.1-4
Published literature shows that at least 45 million people visit eye care clinics annually. Our internal research has shown that 58% of patients presenting at eye care offices have collarettes, a pathognomonic sign of Demodex infestation.5-6
We believe that the prevalence of Demodex blepharitis in the United States may be as high as ~25 million.5-6
Demodex blepharitis is caused by infestation of Demodex mites, the most common ectoparasite found on humans. There are two species of Demodex—folliculorum and brevis—that live on the skin of the face and eyelids.
Published literature has confirmed the pathognomonic relationship between collarettes and Demodex blepharitis. In a study conducted by Gao et al.,100% of patients with at least one collarette had Demodex blepharitis.7
Confirming the presence of collarettes during slit lamp examination is most easily accomplished when the patient looks down.
1. Data on file. Tarsus Pharmaceuticals, Inc. 2019. 2. Howden LM, Meyer JA. Age and Sex Composition: 2010. United States Census Bureau, Department of Commerce, Economics and Statistics Administration. 2011. 3. Paulsen AJ, Cruickshanks KJ, Fischer ME, et al. Dry Eye in the Beaver Dam Offspring Study: Prevalence, Risk Factors, and Health-Related Quality of Life. Am J Ophthalmol. 2014;157(4):799–806. 4. Schaumberg DA, Nichols JJ, Papas EB, Tong L, Uchino M, Nichols KK. The International Workshop on Meibomian Gland Dysfunction: Report of the Subcommittee on the Epidemiology of, and Associated Risk Factors for, MGD. Investig. Ophthalmol. Vis. Sci. 2011;52(4):1994–2005. 5. Wilson FA, Stimpson JP, Wang Y. Inconsistencies Exist in National Estimates of EyeCare Services Utilization in the United States. J. Ophthalmol. 2015; 2015:435606. doi: 10.1155/2015/435606. Accessed 01/25/2020. 6. Data on file. Tarsus Pharmaceuticals, Inc. 2020. 7. Gao Y, Di Pascuale MA, Li W, et al. High Prevalence of Demodex in Eyelashes with Cylindrical Dandruff. Investig. Ophthalmol. Vis. Sci. 2005;46(9):3089–3094.
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