Demodex blepharitis is a pervasive and damaging ocular disease that occurs across the United States1-3
  • Prevalence
  • Patient Burden
  • Identification

Demodex Blepharitis

Demodex mites are a leading cause of blepharitis in the United States, which is characterized by inflammation of the eyelid.2,4

Number of people with Demodex blepharitis in the Unites States.

The prevalence of Demodex blepharitis in the United States may be as high as 25 million.1,5

Published literature shows that at least 45 million people visit eye care clinics annually. 58% of patients presenting at eye care offices have collarettes, a pathognomonic sign of Demodex blepharitis.1,5,6

shape
80%
of patients say Demodex blepharitis has a negative impact on their daily lives.3
In a clinical study, the majority of patients experienced2:
  • Signs and symptoms for >4 years
  • Their top symptoms of itchy eyes or dryness either frequently or all the time
When asked how Demodex blepharitis affects their daily lives, most patients reported3:
  • Difficulty wearing makeup
  • Constantly worrying about their eyes
  • Difficulty driving at night
  • Negative appearance of eyes or eyelids
Patient with Demodex blepharitis.

Learn how Demodex mites cause blepharitis

Demodex blepharitis is caused by an infestation of Demodex mites, the most common ectoparasite found on humans. There are two species of Demodex—D folliculorum and D brevis—that live on the skin of the face and eyelids.

Demodex folliculorum

Demodex
folliculorum

Demodex brevis

Demodex brevis

Demodex blepharitis can be hiding in plain sight

Demodex blepharitis can be confidently diagnosed by looking for collarettes. Simply have patients look down during a routine eye exam to check for collarettes on the upper lid margin.

Slit lamp evaluation, 1.0x magnification Patient looking straight ahead in a slit lamp.
Patient looking straight ahead.
Patient looking straight ahead with lid lift.
Slit lamp evaluation, 1.0x magnification Patient looking down in a slit lamp.
Patient looking down, diffuse collarettes.

Published literature has shown that 100% of patients with collarettes have Demodex blepharitis.6

Collarettes are frequently found in various patient groups1,7

In a clinical study of 1032 patients1,7:

Type of patients with collarettes.
References:

1. Sadri E, Yeu E, Trattler W, Holdbrook M, Baba S. The prevalence of collarettes and Demodex blepharitis in ophthalmology and optometry practices. Presented at: ASCRS 2021. Abstract 75009. 2. Schachter S, Yeu E, Holdbrook M, Baba S, Gomes PJ. Clinical manifestations of Demodex blepharitis. Presented at: ARVO 2021. Abstract 3546575. 3. Yeu E, Holdbrook M, Baba S, Gomes PJ. Psychosocial impact of Demodex blepharitis. Presented at: ARVO 2021. Abstract 3544849. 4. Boyd K. What is blepharitis? American Academy of Ophthalmology. Published June 30, 2021. Accessed July 8, 2021. https://www.aao.org/eye-health/diseases/what-is-blepharitis 5. Wilson FA, Stimpson JP, Wang Y. Inconsistencies exist in the national estimates of eye care services utilization in the United States. J Ophthalmol. doi:10.1155/2015/435606. 6. Gao YY, Di Pascuale MA, Li W, et al. High prevalence of Demodex in eyelashes with cylindrical dandruff. Invest Ophthalmol Vis Sci. 2005;46(9):3089-3094. 7. Data on file. Tarsus Pharmaceuticals, Inc. 2021.

Contact Tarsus

Please reach out to us using the form below.

General Information
Investor Relations
Opt in to be the first to receive the latest Tarsus news
Contact Tarsus

Thank you for getting in touch! Someone from our team will respond shortly.