Our Therapies

The first and only FDA-approved
treatment for Demodex blepharitis

Careers

Proven science. New technology.

Our pipeline is anchored by lotilaner, the active ingredient in XDEMVY®, which has the potential to treat a multitude of diseases by targeting their root causes.

We’re looking for new ways to apply proven science to solve large problems.

Our pipeline of wholly owned candidates addresses a number of diseases with high unmet needs across a range of therapeutic categories including eye care, dermatology and infectious disease prevention.

Candidate
Indication
Preclinical
Phase 1
Phase 2
Phase 3
MARKETED
XDEMVY
XDEMVY®
(TP-03)
Demodex blepharitis (US)
Demodex blepharitis and meibomian gland disease in China (partnership with Grand Pharmaceutical Group)
Demodex blepharitis (preservative free)
Preservative-free formulation to be tested after NDA submission
XDEMVY
TP-04
Rosacea
XDEMVY
TP-05
Lyme disease
Malaria
XDEMVY
XDEMVY®
(TP-03)
XDEMVY
TP-04
XDEMVY
TP-05
Preclinical
Phase 1
Phase 2
Phase 3
MARKETED
Demodex blepharitis (US)
Demodex blepharitis and meibomian gland disease in China (partnership with Grand Pharmaceutical Group)
Demodex blepharitis (preservative free)
Preservative-free formulation to be tested after NDA submission
Preclinical
Phase 1
Phase 2
Phase 3
MARKETED
Rosacea
Preclinical
Phase 1
Phase 2
Phase 3
MARKETED
Lyme disease
Malaria

Setting a target on unmet needs

Many parasite-mediated diseases have high unmet clinical needs. By applying our unique approach to research and development, we’re investigating solutions to target rosacea, Lyme disease prevention and community reduction of malaria.

PPR is a chronic skin disease characterized by facial redness, inflammatory lesions and burning and stinging, which can flare up in response to certain triggers such as sun exposure or emotional stress. According to the US National Rosacea Society, approximately 16 million people in the United States are affected by rosacea. PPR is estimated to occur in 18% to 28% of patients with rosacea. We are developing TP-04 as a topical formulation.

Lyme disease is the most common vector-borne disease in the United States, caused by an infection of Borrelia bacteria following a bite by a tick. Estimates of annual cases of Lyme disease in the United States range from approximately 300,000 to 400,000. We are developing TP-05 as an oral formulation that is designed to be a prophylactic drug against Lyme disease to eradicate the tick before it can transmit the Borrelia bacteria. TP-05 also has the potential to cause the death of mosquitos that transmit malaria. Malaria is one of the world’s highest unmet public health needs, with approximately 247 million cases and more than 600,000 deaths worldwide.

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