Our Therapies

The first and only FDA-approved
treatment for Demodex blepharitis

Careers

Proven science. New technology.

Our pipeline is anchored by lotilaner, the active ingredient in XDEMVY®, which has the potential to treat a multitude of diseases by targeting their root causes.

We’re looking for new ways to apply proven science to solve large problems.

Our pipeline of wholly owned candidates addresses a number of diseases with high unmet needs across a range of therapeutic categories, including eye care and infectious disease prevention.

Candidate
PROPOSED
Indication
Preclinical
Phase 1
Phase 2
Phase 3
MARKETED
XDEMVY
XDEMVY®
(TP-03)
Demodex blepharitis (US)
Demodex blepharitis in China (partnership with Grand Pharmaceutical Group)
Demodex blepharitis
(EU; preservative free)
XDEMVY
TP-04
Ocular rosacea
XDEMVY
TP-05
Lyme disease
Malaria
XDEMVY
XDEMVY®
(TP-03)
XDEMVY
TP-04
XDEMVY
TP-05
Preclinical
Phase 1
Phase 2
Phase 3
MARKETED
Demodex blepharitis (US)
Demodex blepharitis in China (partnership with Grand Pharmaceutical Group)
Demodex blepharitis
(EU; preservative free)
Preclinical
Phase 1
Phase 2
Phase 3
MARKETED
Ocular rosacea
Preclinical
Phase 1
Phase 2
Phase 3
MARKETED
Lyme disease
Malaria

Setting a target on unmet needs

Many parasite-mediated diseases have high unmet clinical needs. By applying our unique approach to research and development, we’re investigating solutions to target ocular rosacea, Lyme disease prevention and community reduction of malaria.

Ocular rosacea is a common inflammatory condition of the eyes that impacts 15-18 million people in the United States. Characterized by redness, irritation and dryness in and around the eyes, the National Rosacea Society estimates that ocular rosacea may exist in up to 60% of patients with rosacea. Ocular rosacea is thought to be caused by vascular, immune and/or other microbial factors that result in inflammation, including an overgrowth of Demodex mites, and there are currently no FDA-approved treatments available to treat it.

Lyme disease is the most common vector-borne disease in the United States, caused by an infection of Borrelia bacteria following a bite by a tick. Estimates of annual cases of Lyme disease in the United States range from approximately 300,000 to 400,000. We are developing TP-05 as an oral formulation that is designed to be a prophylactic drug against Lyme disease to eradicate the tick before it can transmit the Borrelia bacteria. TP-05 also has the potential to cause the death of mosquitos that transmit malaria. Malaria is one of the world’s highest unmet public health needs, with approximately 247 million cases and more than 600,000 deaths worldwide.

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